5Z8G

BRD4 Bromodomain 1 with an inhibitor

Summary for 5Z8G

DescriptorBromodomain-containing protein 4, 1-ethyl-6-[(3R)-3-oxidanylpiperidin-1-yl]sulfonyl-benzo[cd]indol-2-one, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywordsbrd4 bromodomain 1, inhibitor, complex, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight15537.94
Authors
Xiao, S.,Chen, S.,Chen, H. (deposition date: 2018-01-31, release date: 2019-02-06)
Primary citation
Xiao, S.,Chen, S.,Chen, H.
BRD4 Bromodomain 1 with an inhibitor
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.701 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21212 0.8% 2.6% 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5z8g
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Molmil generated image of 5z8g
rotated about x axis by 90°
Molmil generated image of 5z8g
rotated about y axis by 90°
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