5Z79

Crystal Structure Analysis of the HPPK-DHPS in complex with substrates

Summary for 5Z79

Entry DOI	10.2210/pdb5z79/pdb
Descriptor	Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (8 entities in total)
Functional Keywords	trasnferase, bifunctional, malaria pterin, substrates, transferase
Biological source	Plasmodium vivax (malaria parasite P. vivax)
Total number of polymer chains	6
Total formula weight	500109.67
Authors	Manickam, Y.,Karl, H.,Sharma, A. (deposition date: 2018-01-27, release date: 2018-08-29, Last modification date: 2023-11-22)
Primary citation	Yogavel, M.,Nettleship, J.E.,Sharma, A.,Harlos, K.,Jamwal, A.,Chaturvedi, R.,Sharma, M.,Jain, V.,Chhibber-Goel, J.,Sharma, A. Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance J. Biol. Chem., 293:14962-14972, 2018 Cited by PubMed: 30104413 DOI: 10.1074/jbc.RA118.004558 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation