5Z79

Crystal Structure Analysis of the HPPK-DHPS in complex with substrates

5Z79 の概要

• エントリーDOI: 10.2210/pdb5z79/pdb
• 分子名称: Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (8 entities in total)
• 機能のキーワード: trasnferase, bifunctional, malaria pterin, substrates, transferase
• 由来する生物種: Plasmodium vivax (malaria parasite P. vivax)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 500109.67

構造登録者

Manickam, Y.,Karl, H.,Sharma, A. (登録日: 2018-01-27, 公開日: 2018-08-29, 最終更新日: 2023-11-22)

• 主引用文献: Yogavel, M.,Nettleship, J.E.,Sharma, A.,Harlos, K.,Jamwal, A.,Chaturvedi, R.,Sharma, M.,Jain, V.,Chhibber-Goel, J.,Sharma, A.; Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance; J. Biol. Chem., 293:14962-14972, 2018; PubMed: 30104413; DOI: 10.1074/jbc.RA118.004558

実験手法

X-RAY DIFFRACTION (2.9 Å)