5Z1C
The crystal structure of uPA in complex with 4-Iodobenzylamine at pH7.4
Summary for 5Z1C
Entry DOI | 10.2210/pdb5z1c/pdb |
Descriptor | Urokinase-type plasminogen activator, 1-(4-iodophenyl)methanamine (3 entities in total) |
Functional Keywords | halogen bonding, serine protease, upa, p1 group, protease inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27819.47 |
Authors | Jiang, L.G.,Zhang, X.,Luo, Z.P.,Huang, M.D. (deposition date: 2017-12-25, release date: 2018-12-26, Last modification date: 2023-11-22) |
Primary citation | Jiang, L.G.,Zhang, X.,Zhou, Y.,Chen, Y.Y.,Luo, Z.P.,Li, J.Y.,Yuan, C.,Huang, M.D. Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases Rsc Adv, 49:28189-28197, 2018 Cited by DOI: 10.1039/c8ra03145bPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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