5Z0S

Crystal structure of FGFR1 kinase domain in complex with a novel inhibitor

Summary for 5Z0S

• Entry DOI: 10.2210/pdb5z0s/pdb
• Descriptor: Fibroblast growth factor receptor 1, 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridine (3 entities in total)
• Functional Keywords: fgfr1 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 70986.23

Authors

Liu, Q.,Xu, Y. (deposition date: 2017-12-20, release date: 2018-12-26, Last modification date: 2023-11-22)

• Primary citation: Jiang, A.,Liu, Q.,Wang, R.,Wei, P.,Dai, Y.,Wang, X.,Xu, Y.,Ma, Y.,Ai, J.,Shen, J.,Ding, J.,Xiong, B.; Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors; Molecules, 23:-, 2018; PubMed: 29562726; DOI: 10.3390/molecules23030698

Experimental method

X-RAY DIFFRACTION (2.45 Å)