5YWX

Crystal structure of hematopoietic prostaglandin D synthase in complex with F092

5YWX の概要

• エントリーDOI: 10.2210/pdb5ywx/pdb
• 分子名称: Hematopoietic prostaglandin D synthase, GLUTATHIONE, N-[4-(2-oxopyrrolidin-1-yl)phenyl]-2-(pyridin-2-yl)pyrimidine-5-carboxamide, ... (6 entities in total)
• 機能のキーワード: prostaglandin, synthase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95950.26

構造登録者

Kamo, M.,Furubayashi, N.,Inaka, K.,Aritake, K.,Omura, A.,Tanaka, A. (登録日: 2017-11-30, 公開日: 2018-09-05, 最終更新日: 2023-11-22)

• 主引用文献: Takaya, D.,Inaka, K.,Omura, A.,Takenuki, K.,Kawanishi, M.,Yabuki, Y.,Nakagawa, Y.,Tsuganezawa, K.,Ogawa, N.,Watanabe, C.,Honma, T.,Aritake, K.,Urade, Y.,Shirouzu, M.,Tanaka, A.; Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies.; Bioorg. Med. Chem., 26:4726-4734, 2018; PubMed: 30121213; DOI: 10.1016/j.bmc.2018.08.014

実験手法

X-RAY DIFFRACTION (1.74 Å)