5YRS

X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate

「3MIM」から置き換えられました

5YRS の概要

• エントリーDOI: 10.2210/pdb5yrs/pdb
• 関連するPDBエントリー: 1G6L 1LV1 2NPH
• 分子名称: PROTEASE, RT-RH oligopeprtide, ... (4 entities in total)
• 機能のキーワード: hiv-1 protease, tetrahedral intermediate, short ionic hydrogen bond, substrate complex, rt-rh, hydrolase
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 23040.88

構造登録者

Das, A.,Mahale, S.,Prashar, V.,Bihani, S.,Ferrer, J.-L.,Hosur, M.V. (登録日: 2017-11-10, 公開日: 2018-03-07, 最終更新日: 2023-11-22)

• 主引用文献: Das, A.,Mahale, S.,Prashar, V.,Bihani, S.,Ferrer, J.L.,Hosur, M.V.; X-ray snapshot of HIV-1 protease in action: observation of tetrahedral intermediate and short ionic hydrogen bond SIHB with catalytic aspartate.; J. Am. Chem. Soc., 132:6366-6373, 2010; PubMed: 20397633; DOI: 10.1021/ja100002b

実験手法

X-RAY DIFFRACTION (1.76 Å)