5YP2

Crystal structure of dipeptidyl peptidase IV (DPP IV) with DPP4 inhibitor from Pseudoxanthomonas mexicana WO24

Summary for 5YP2

Entry DOI	10.2210/pdb5yp2/pdb
Related	5YP1 5YP3 5YP4
Descriptor	Dipeptidyl aminopeptidase 4, (2S,5R)-1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]ethanoyl]pyrrolidine-2,5-dicarbonitrile, GLYCEROL, ... (4 entities in total)
Functional Keywords	dap iv, clan sc s9, peptidase, dpp4, dpp8, dpp9, hydrolase
Biological source	Pseudoxanthomonas mexicana (Pseudomonas sp. WO24)
Cellular location	Isoform 2: Cytoplasm . Isoform 1: Periplasm : Q6F3I7
Total number of polymer chains	2
Total formula weight	165579.95
Authors	Roppongi, S.,Suzuki, Y.,Tateoka, C.,Fuimoto, M.,Morisawa, S.,Iizuka, I.,Nakamura, A.,Honma, N.,Shida, Y.,Ogasawara, W.,Tanaka, N.,Sakamoto, Y.,Nonaka, T. (deposition date: 2017-11-01, release date: 2018-02-21, Last modification date: 2023-11-22)
Primary citation	Roppongi, S.,Suzuki, Y.,Tateoka, C.,Fujimoto, M.,Morisawa, S.,Iizuka, I.,Nakamura, A.,Honma, N.,Shida, Y.,Ogasawara, W.,Tanaka, N.,Sakamoto, Y.,Nonaka, T. Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues. Sci Rep, 8:2714-2714, 2018 Cited by PubMed: 29426867 DOI: 10.1038/s41598-018-21056-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation