5YLT

Crystal structure of SET7/9 in complex with a cyproheptadine derivative

Summary for 5YLT

Entry DOI	10.2210/pdb5ylt/pdb
Descriptor	Histone-lysine N-methyltransferase SETD7, SINEFUNGIN, 2-(1-methylpiperidin-4-ylidene)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-6-ol, ... (5 entities in total)
Functional Keywords	set domain, methyltransferase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30044.31
Authors	Hirano, T.,Fujiwara, T.,Niwa, H.,Hirano, M.,Ohira, K.,Okazaki, Y.,Sato, S.,Umehara, T.,Maemoto, Y.,Ito, A.,Yoshida, M.,Kagechika, H. (deposition date: 2017-10-19, release date: 2018-06-20, Last modification date: 2023-11-22)
Primary citation	Hirano, T.,Fujiwara, T.,Niwa, H.,Hirano, M.,Ohira, K.,Okazaki, Y.,Sato, S.,Umehara, T.,Maemoto, Y.,Ito, A.,Yoshida, M.,Kagechika, H. Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine. ChemMedChem, 13:1530-1540, 2018 Cited by PubMed: 29882380 DOI: 10.1002/cmdc.201800233 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation