5YJF

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with small molecule analog of Nicotinamide

5YJF の概要

• エントリーDOI: 10.2210/pdb5yjf/pdb
• 分子名称: Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 6-methoxy-1-methyl-2H-pyridine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: nnmt, na, mna, t2d, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P40261
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128627.15

構造登録者

Swaminathan, S.,Birudukota, S.,Thakur, M.K.,Parveen, R.,Kandan, S.,Hallur, M.S.,Rajagopal, S.,Ruf, S.,Dhakshinamoorthy, S.,Kannt, A.,Gosu, R. (登録日: 2017-10-10, 公開日: 2018-03-21, 最終更新日: 2023-11-22)

• 主引用文献: Kannt, A.,Rajagopal, S.,Kadnur, S.V.,Suresh, J.,Bhamidipati, R.K.,Swaminathan, S.,Hallur, M.S.,Kristam, R.,Elvert, R.,Czech, J.,Pfenninger, A.,Rudolph, C.,Schreuder, H.,Chandrasekar, D.V.,Mane, V.S.,Birudukota, S.,Shaik, S.,Zope, B.R.,Burri, R.R.,Anand, N.N.,Thakur, M.K.,Singh, M.,Parveen, R.,Kandan, S.,Mullangi, R.,Yura, T.,Gosu, R.,Ruf, S.,Dhakshinamoorthy, S.; A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.; Sci Rep, 8:3660-3660, 2018; PubMed: 29483571; DOI: 10.1038/s41598-018-22081-7

実験手法

X-RAY DIFFRACTION (2.49 Å)