5YIB

Crystal Structure of KNI-10743 bound Plasmepsin II (PMII) from Plasmodium falciparum

5YIB の概要

• エントリーDOI: 10.2210/pdb5yib/pdb
• 分子名称: Plasmepsin II, (4R)-3-[(2S,3S)-3-[2-[4-[2-(dimethylamino)ethyl-methyl-amino]-2,6-dimethyl-phenoxy]ethanoylamino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: plasmepsin, plasmepsin ii, kni-10743, aspartic protease, plasmodium falciparum, drug development, inhibitor, hydrolase
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38788.07

構造登録者

Rathore, I.,Mishra, V.,Bhaumik, P. (登録日: 2017-10-03, 公開日: 2018-07-11, 最終更新日: 2019-05-29)

• 主引用文献: Mishra, V.,Rathore, I.,Arekar, A.,Sthanam, L.K.,Xiao, H.,Kiso, Y.,Sen, S.,Patankar, S.,Gustchina, A.,Hidaka, K.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P.; Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.; Febs J., 285:3077-3096, 2018; PubMed: 29943906; DOI: 10.1111/febs.14598

実験手法

X-RAY DIFFRACTION (2.15 Å)