5YGI
Crystal structure of human FPPS in complex with an inhibitor THZ93
Summary for 5YGI
Entry DOI | 10.2210/pdb5ygi/pdb |
Descriptor | Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | thz93, complex, human fpps, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40660.81 |
Authors | |
Primary citation | Xia, Y.,Xie, Y.,Yu, Z.,Xiao, H.,Jiang, G.,Zhou, X.,Yang, Y.,Li, X.,Zhao, M.,Li, L.,Zheng, M.,Han, S.,Zong, Z.,Meng, X.,Deng, H.,Ye, H.,Fa, Y.,Wu, H.,Oldfield, E.,Hu, X.,Liu, W.,Shi, Y.,Zhang, Y. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell, 175:1059-1073.e21, 2018 Cited by PubMed: 30270039DOI: 10.1016/j.cell.2018.08.070 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.177 Å) |
Structure validation
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