5YG4

Plasmodium vivax SHMT bound with PLP-glycine and S-GS849

Summary for 5YG4

Entry DOI	10.2210/pdb5yg4/pdb
Descriptor	Serine hydroxymethyltransferase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], 2-[1-[(3~{S})-6'-azanyl-5'-cyano-7-fluoranyl-2,2,3'-trimethyl-spiro[1~{H}-indene-3,4'-2~{H}-pyrano[2,3-c]pyrazole]-5-yl]piperidin-4-yl]ethanoic acid, ... (6 entities in total)
Functional Keywords	alpha and beta protein, transferase, methyltransferase activity, inhibitor, transferase-inhibitor complex, transferase/inhibitor
Biological source	Plasmodium vivax
Total number of polymer chains	3
Total formula weight	150409.86
Authors	Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U.,Schwertz, G.,Diederich, F. (deposition date: 2017-09-22, release date: 2018-06-06, Last modification date: 2023-11-22)
Primary citation	Schwertz, G.,Witschel, M.C.,Rottmann, M.,Leartsakulpanich, U.,Chitnumsub, P.,Jaruwat, A.,Amornwatcharapong, W.,Ittarat, W.,Schafer, A.,Aponte, R.A.,Trapp, N.,Chaiyen, P.,Diederich, F. Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold ChemMedChem, 13:931-943, 2018 Cited by PubMed: 29655285 DOI: 10.1002/cmdc.201800053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation