5YG0
Plasmodium vivax SHMT bound with PLP-glycine and GS657
Summary for 5YG0
Entry DOI | 10.2210/pdb5yg0/pdb |
Descriptor | Serine hydroxymethyltransferase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], 2-[1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]piperidin-4-yl]ethanoic acid, ... (5 entities in total) |
Functional Keywords | alpha and beta protein, transferase, methyltransferase activity, inhibitor, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Plasmodium vivax |
Total number of polymer chains | 3 |
Total formula weight | 150247.56 |
Authors | Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U.,Schwertz, G.,Diederich, F. (deposition date: 2017-09-22, release date: 2018-09-26, Last modification date: 2023-11-22) |
Primary citation | Chitnumsub, P.,Jaruwat, A. to be published to be published, |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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