5YF9

Crystal structure of CK2a2 form-2

5YF9 の概要

• エントリーDOI: 10.2210/pdb5yf9/pdb
• 分子名称: Casein kinase II subunit alpha', NICOTINIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81334.69

構造登録者

Tsuyuguchi, M.,Kinoshita, T. (登録日: 2017-09-20, 公開日: 2018-05-16, 最終更新日: 2023-11-22)

主引用文献

Tsuyuguchi, M.,Nakaniwa, T.,Kinoshita, T.
Crystal structures of human CK2 alpha 2 in new crystal forms arising from a subtle difference in salt concentration
Acta Crystallogr F Struct Biol Commun, 74:288-293, 2018

PubMed Abstract: The catalytic subunits of protein kinase CK2 are classified into two subtypes: CK2α1 and CK2α2. CK2α1 is an attractive drug-discovery target for various diseases such as cancers and nephritis. CK2α2 is defined as an off-target of CK2α1 and is a potential target in the development of male contraceptive drugs. High-resolution crystal structures of both isozymes are likely to provide crucial clues for the design of selective inhibitors of CK2α1 and/or CK2α2. To date, several crystal structures of CK2α1 have been solved at high resolutions of beyond 1.5 Å. However, crystal structures of CK2α2 have barely achieved a low resolution of around 3 Å because of the formation of needle-shaped crystals. In this study, new crystal forms were exploited and one provided a crystal structure of CK2α2 at 1.89 Å resolution. This result, together with the structure of CK2α1, will assist in the development of highly selective inhibitors for both isozymes.

PubMed: 29717996
DOI: 10.1107/S2053230X18005204

実験手法

X-RAY DIFFRACTION (1.89 Å)