5YEW

Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion

Summary for 5YEW

• Entry DOI: 10.2210/pdb5yew/pdb
• Descriptor: Mitofusin-1,Mitofusin-1 fusion protein, GUANOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... (6 entities in total)
• Functional Keywords: mitochondria, fusion, mfn1, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Mitochondrion outer membrane ; Multi- pass membrane protein . Isoform 2: Cytoplasm : Q8IWA4 Q8IWA4
• Total number of polymer chains: 3
• Total formula weight: 143909.49

Authors

Yan, L.,Qi, Y.,Huang, X.,Yu, C. (deposition date: 2017-09-20, release date: 2018-01-31, Last modification date: 2024-03-06)

• Primary citation: Yan, L.,Qi, Y.,Huang, X.,Yu, C.,Lan, L.,Guo, X.,Rao, Z.,Hu, J.,Lou, Z.; Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion; Nat. Struct. Mol. Biol., 25:233-243, 2018; PubMed: 29483649; DOI: 10.1038/s41594-018-0034-8

Experimental method

X-RAY DIFFRACTION (3.2 Å)