5YEK

Crystal structure of BioQ

Summary for 5YEK

Entry DOI	10.2210/pdb5yek/pdb
Descriptor	TetR family transcriptional regulator (2 entities in total)
Functional Keywords	bioq, dna complex, tetr family, dna binding protein
Biological source	Mycobacterium smegmatis
Total number of polymer chains	2
Total formula weight	50414.00
Authors	Yan, L.,Guan, Z.Y.,Zou, T.T. (deposition date: 2017-09-17, release date: 2018-09-26, Last modification date: 2023-11-22)
Primary citation	Yan, L.,Tang, Q.,Guan, Z.,Pei, K.,Zou, T.,He, J. Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway. Biochim Biophys Acta Gen Subj, 1862:1843-1851, 2018 Cited by PubMed Abstract: Biotin is an essential cofactor in living organisms. The TetR family transcriptional regulator (TFTR) BioQ is the main regulator of biotin synthesis in Mycobacterium smegmatis. BioQ represses the expression of its target genes by binding to a conserved palindromic DNA sequence (the BioQ operator). However, the mechanism by which BioQ recognizes this DNA element has not yet been fully elucidated. PubMed: 29852200 DOI: 10.1016/j.bbagen.2018.05.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.191 Å)

Structure validation