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5YC8

Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS (Hg-derivative)

Summary for 5YC8
Entry DOI10.2210/pdb5yc8/pdb
Related5XB9 5XBA 5XBB 5XBG
DescriptorMuscarinic acetylcholine receptor M2,Redesigned apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine, MERCURY (II) ION, ... (4 entities in total)
Functional Keywordsgpcr crystallography, rationally thermostabilized mutant, membrane protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight48213.36
Authors
Primary citationSuno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T.
Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14:1150-1158, 2018
Cited by
PubMed: 30420692
DOI: 10.1038/s41589-018-0152-y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

건을2024-03-27부터공개중

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