5Y7J

Crystal structure of human DPP4 in complex with inhibitor2

Summary for 5Y7J

• Entry DOI: 10.2210/pdb5y7j/pdb
• Descriptor: Dipeptidyl peptidase 4, (S)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one (3 entities in total)
• Functional Keywords: dpp4, inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 339456.16

Authors

Lee, H.K.,Kim, E.E. (deposition date: 2017-08-17, release date: 2019-03-20, Last modification date: 2023-11-22)

• Primary citation: Lee, H.K.,Kim, M.K.,Kim, H.D.,Kim, H.J.,Kim, J.W.,Lee, J.O.,Kim, C.W.,Kim, E.E.; Unique binding mode of Evogliptin with human dipeptidyl peptidase IV.; Biochem.Biophys.Res.Commun., 494:452-459, 2017; PubMed: 29061303; DOI: 10.1016/j.bbrc.2017.10.101

Experimental method

X-RAY DIFFRACTION (2.521 Å)