5Y6E
VIM-2 metallo-beta-lactamase in complex with (R)-2-(4-hydroxyphenyl)-2-((S)-3-mercapto-2-methylpropanamido)acetic acid (compound 12)
Summary for 5Y6E
Entry DOI | 10.2210/pdb5y6e/pdb |
Descriptor | Beta-lactamase class B VIM-2, ZINC ION, (2R)-2-(4-hydroxyphenyl)-2-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]ethanoic acid, ... (5 entities in total) |
Functional Keywords | metallo-beta-lactamase vim-2, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 50474.07 |
Authors | Li, G.-B. (deposition date: 2017-08-11, release date: 2018-01-24, Last modification date: 2023-11-22) |
Primary citation | Liu, S.,Jing, L.,Yu, Z.-J.,Wu, C.,Zheng, Y.,Zhang, E.,Chen, Q.,Yu, Y.,Guo, L.,Wu, Y.,Li, G.-B. ((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-beta-lactamase inhibitors: Synthesis, kinetic and crystallographic studies. Eur J Med Chem, 145:649-660, 2018 Cited by PubMed: 29353720DOI: 10.1016/j.ejmech.2018.01.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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