5Y5U

Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor

5Y5U の概要

• エントリーDOI: 10.2210/pdb5y5u/pdb
• 分子名称: Tyrosine-protein kinase SYK, 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one (3 entities in total)
• 機能のキーワード: inhibitor, spleen tyrosine kinase, human kinase, drug discovery, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69215.65

構造登録者

Lee, S.J.,Lee, B.I. (登録日: 2017-08-09, 公開日: 2018-06-27, 最終更新日: 2023-11-22)

• 主引用文献: Lee, S.J.,Choi, J.S.,Bong, S.M.,Hwang, H.J.,Lee, J.,Song, H.J.,Lee, J.,Kim, J.H.,Koh, J.S.,Lee, B.I.; Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.; Mol. Cells, 41:545-552, 2018; PubMed: 29890824; DOI: 10.14348/molcells.2018.2219

実験手法

X-RAY DIFFRACTION (2.14 Å)