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5Y5N

Crystal structure of human Sirtuin 2 in complex with a selective inhibitor

Summary for 5Y5N
Entry DOI10.2210/pdb5y5n/pdb
DescriptorNAD-dependent protein deacetylase sirtuin-2, ZINC ION, 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide, ... (4 entities in total)
Functional Keywordspseudopeptides, anticancer activity, neurite outgrowth, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight38234.19
Authors
Mellini, P.,Itoh, Y.,Tsumoto, H.,Li, Y.,Suzuki, M.,Tokuda, N.,Kakizawa, T.,Miura, Y.,Takeuchi, J.,Lahtela-Kakkonen, M.,Suzuki, T. (deposition date: 2017-08-09, release date: 2017-09-06, Last modification date: 2023-11-22)
Primary citationMellini, P.,Itoh, Y.,Tsumoto, H.,Li, Y.,Suzuki, M.,Tokuda, N.,Kakizawa, T.,Miura, Y.,Takeuchi, J.,Lahtela-Kakkonen, M.,Suzuki, T.
Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.
Chem Sci, 8:6400-6408, 2017
Cited by
PubMed: 28989670
DOI: 10.1039/c7sc02738a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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