5Y4Z

Crystal structure of the Zika virus NS3 helicase complex with AMPPNP

Summary for 5Y4Z

• Entry DOI: 10.2210/pdb5y4z/pdb
• Descriptor: NS3 helicase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: zika virus, ns3 helicase, amppnp, hydrolase
• Biological source: Zika virus (strain Mr 766) (ZIKV)
• Cellular location: Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: Q32ZE1
• Total number of polymer chains: 1
• Total formula weight: 50074.76

Authors

Li, L. (deposition date: 2017-08-06, release date: 2017-08-30, Last modification date: 2024-03-27)

• Primary citation: Li, L.,Wang, J.,Jia, Z.,Shaw, N.; Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA; Acta Crystallogr.,Sect.F, 74:205-213, 2018; DOI: 10.1107/S2053230X18003813

Experimental method

X-RAY DIFFRACTION (1.3 Å)