5Y4Q

Crystal structure of Trypanosoma cruzi spermidine synthase in complex with N-(4-methoxyphenyl)quinolin-4-amine

Summary for 5Y4Q

Entry DOI	10.2210/pdb5y4q/pdb
Descriptor	Spermidine synthase, putative, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, N-(4-methoxyphenyl)quinolin-4-amine, ... (4 entities in total)
Functional Keywords	polyamine synthesis, transferase
Biological source	Trypanosoma cruzi (strain CL Brener)
Total number of polymer chains	4
Total formula weight	138841.85
Authors	Amano, Y.,Tateishi, Y. (deposition date: 2017-08-04, release date: 2018-08-08, Last modification date: 2023-12-06)
Primary citation	Yoshino, R.,Yasuo, N.,Hagiwara, Y.,Ishida, T.,Inaoka, D.K.,Amano, Y.,Tateishi, Y.,Ohno, K.,Namatame, I.,Niimi, T.,Orita, M.,Kita, K.,Akiyama, Y.,Sekijima, M. Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro , and X-ray Crystallography. Acs Omega, 8:25850-25860, 2023 Cited by PubMed: 37521650 DOI: 10.1021/acsomega.3c01314 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation