5Y4P

Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 5-methoxy-2-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenol

5Y4P の概要

• エントリーDOI: 10.2210/pdb5y4p/pdb
• 分子名称: Spermidine synthase, putative, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, 5-methoxy-2-[(5R)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]phenol, ... (4 entities in total)
• 機能のキーワード: polyamine synthesis, transferase
• 由来する生物種: Trypanosoma cruzi (strain CL Brener)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 138665.63

構造登録者

Amano, Y.,Tateishi, Y. (登録日: 2017-08-04, 公開日: 2018-08-08, 最終更新日: 2023-12-06)

• 主引用文献: Yoshino, R.,Yasuo, N.,Hagiwara, Y.,Ishida, T.,Inaoka, D.K.,Amano, Y.,Tateishi, Y.,Ohno, K.,Namatame, I.,Niimi, T.,Orita, M.,Kita, K.,Akiyama, Y.,Sekijima, M.; Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro , and X-ray Crystallography.; Acs Omega, 8:25850-25860, 2023; PubMed: 37521650; DOI: 10.1021/acsomega.3c01314

実験手法

X-RAY DIFFRACTION (2.16 Å)