5Y1Y
Complex structure of nitroxoline with the first bromodomain of BRD4
Summary for 5Y1Y
Entry DOI | 10.2210/pdb5y1y/pdb |
Descriptor | Bromodomain-containing protein 4, 5-nitroquinolin-8-ol (3 entities in total) |
Functional Keywords | brd4 inhibitor approved drugs, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15073.34 |
Authors | |
Primary citation | Jiang, H.,Xing, J.,Wang, C.,Zhang, H.,Yue, L.,Wan, X.,Chen, W.,Ding, H.,Xie, Y.,Tao, H.,Chen, Z.,Jiang, H.,Chen, K.,Chen, S.,Zheng, M.,Zhang, Y.,Luo, C. Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues. Org. Biomol. Chem., 15:9352-9361, 2017 Cited by PubMed: 29087414DOI: 10.1039/c7ob02369c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.912 Å) |
Structure validation
Download full validation report