5Y0Z

Human SIRT2 in complex with a specific inhibitor, NPD11033

5Y0Z の概要

• エントリーDOI: 10.2210/pdb5y0z/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, (1~{R},9~{S})-11-[(2~{R})-3-[2,4-bis(2-methylbutan-2-yl)phenoxy]-2-oxidanyl-propyl]-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one, ... (4 entities in total)
• 機能のキーワード: sirtuin, sirt, nad-dependent deacetylase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67494.63

構造登録者

Kudo, N.,Ito, A.,Yoshida, M. (登録日: 2017-07-19, 公開日: 2018-07-25, 最終更新日: 2023-11-22)

• 主引用文献: Kudo, N.,Ito, A.,Arata, M.,Nakata, A.,Yoshida, M.; Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.; Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373:-, 2018; PubMed: 29685974; DOI: 10.1098/rstb.2017.0070

実験手法

X-RAY DIFFRACTION (2 Å)