5Y0X
Crystal structure of human FABP4 complexed with ligand 2-fluoro-3-((4-methoxynaphthalene)-1-sulfonamido)benzoic acid
Summary for 5Y0X
Entry DOI | 10.2210/pdb5y0x/pdb |
Descriptor | Fatty acid-binding protein, adipocyte, 2-fluoranyl-3-[(4-methoxynaphthalen-1-yl)sulfonylamino]benzoic acid (3 entities in total) |
Functional Keywords | lipid binding protein, fabp4, inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17286.64 |
Authors | |
Primary citation | Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X. From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 Eur J Med Chem, 154:44-59, 2018 Cited by PubMed: 29775936DOI: 10.1016/j.ejmech.2018.05.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.604 Å) |
Structure validation
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