5Y0B

PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99

Summary for 5Y0B

Entry DOI	10.2210/pdb5y0b/pdb
EMDB information	6799
Descriptor	Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta (2 entities in total)
Functional Keywords	ion pump, h+, k+-atpase, p-type atpase, membrane protein, hydrolase, e2, aluminium fluoride, atp-binding, hydrogen ion transport, ion transport, magnesium, membrane, metal-binding, nucleotide-binding, phosphoprotein, potassium, potassium transport, transmembrane, transport, disulfide bond, glycoprotein, signal-anchor
Biological source	Sus scrofa (Pig) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P19156 Cell membrane ; Single-pass type II membrane protein : P18434
Total number of polymer chains	2
Total formula weight	147513.53
Authors	Abe, K.,Shimokawa, J.,Natio, M.,Munson, K.,Vagin, O.,Sachs, G.,Suzuki, H.,Tani, K.,Fujiyoshi, Y. (deposition date: 2017-07-16, release date: 2017-08-09)
Primary citation	Abe, K.,Shimokawa, J.,Naito, M.,Munson, K.,Vagin, O.,Sachs, G.,Suzuki, H.,Tani, K.,Fujiyoshi, Y. The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors Sci Rep, 7:6632-6632, 2017 Cited by PubMed: 28747707 DOI: 10.1038/s41598-017-06698-8 PDB entries with the same primary citation
Experimental method	ELECTRON CRYSTALLOGRAPHY (6.7 Å)

Structure validation