5Y05
Structural characterization of msmeg_4306 from Mycobacterium smegmatis
Summary for 5Y05
| Entry DOI | 10.2210/pdb5y05/pdb |
| Descriptor | msmeg_4306, ZINC ION (2 entities in total) |
| Functional Keywords | coiled coil helix, zinc ribbon, hypothetical, zinc-sad, unknown function |
| Biological source | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
| Total number of polymer chains | 1 |
| Total formula weight | 29603.38 |
| Authors | Kumar, A.,Karthikeyan, S. (deposition date: 2017-07-14, release date: 2018-05-02, Last modification date: 2024-03-27) |
| Primary citation | Kumar, A.,Karthikeyan, S. Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis Acta Crystallogr F Struct Biol Commun, 74:166-173, 2018 Cited by PubMed Abstract: The MSMEG_4306 gene from Mycobacterium smegmatis encodes a protein of unknown function with 242 amino-acid residues that contains a conserved zinc-ribbon domain at its C-terminus. Here, the crystal structure of MSMEG_4306 determined by the single-wavelength anomalous dispersion method using just one zinc ion co-purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled-coil helix domain in the N-terminal region and a zinc-ribbon domain in the C-terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from Chlamydia trachomatis and HP0958 from Helicobacter pylori, although they share only ∼15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids. PubMed: 29497021DOI: 10.1107/S2053230X18002236 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.799 Å) |
Structure validation
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