5XZG
Mouse cGAS bound to the inhibitor RU521
Summary for 5XZG
Entry DOI | 10.2210/pdb5xzg/pdb |
Descriptor | Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(P*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*TP*T)-3'), ... (6 entities in total) |
Functional Keywords | inhibitor, cgas, sting, immune system-inhibitor complex, immune system/inhibitor |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 51866.56 |
Authors | Vincent, J.,Adura, C.,Gao, P.,Luz, A.,Lama, L.,Asano, Y.,Okamoto, R.,Imaeda, T.,Aida, J.,Rothamel, K.,Gogakos, T.,Steinberg, J.,Reasoner, S.,Aso, K.,Tuschl, T.,Patel, D.J.,Glickman, J.F.,Ascano, M. (deposition date: 2017-07-12, release date: 2017-10-11, Last modification date: 2024-03-13) |
Primary citation | Vincent, J.,Adura, C.,Gao, P.,Luz, A.,Lama, L.,Asano, Y.,Okamoto, R.,Imaeda, T.,Aida, J.,Rothamel, K.,Gogakos, T.,Steinberg, J.,Reasoner, S.,Aso, K.,Tuschl, T.,Patel, D.J.,Glickman, J.F.,Ascano, M. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun, 8:750-750, 2017 Cited by PubMed: 28963528DOI: 10.1038/s41467-017-00833-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.828 Å) |
Structure validation
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