5XZ3

The X-ray structure of Apis mellifera PGRP-SA

Summary for 5XZ3

• Entry DOI: 10.2210/pdb5xz3/pdb
• Descriptor: Peptidoglycan-recognition protein, SULFATE ION (3 entities in total)
• Functional Keywords: apis mellifera, pgrp-sa, immune system
• Biological source: Apis mellifera (Honeybee)
• Total number of polymer chains: 4
• Total formula weight: 79077.53

Authors

Liu, Y.J.,Huang, J.X.,Zhao, X.M.,An, J.D. (deposition date: 2017-07-11, release date: 2018-07-18, Last modification date: 2024-10-16)

Primary citation

Liu, Y.,Zhao, X.,Naeem, M.,An, J.
Crystal structure of peptidoglycan recognition protein SA in Apis mellifera (Hymenoptera: Apidae).
Protein Sci., 27:893-897, 2018

PubMed Abstract: Peptidoglycan recognition protein SA (PGRP-SA) is a key pattern recognition receptor in the insect innate immune system. PGRP-SA can bind to bacterial PGN and activate the Toll pathway, which triggers the expression and release of antimicrobial peptides to prevent bacterial infection. Here, we report the first structure of Apis mellifera PGRP-SA from Hymenoptera at 1.86 Å resolution. The overall architecture of Am-PGRP-SA was similar to the Drosophila PGRP-SA; however, the residues involved in PGN binding groove were not conserved, and the binding pocket was narrower. This structure gives insight into PGN binding characteristics in honeybees.

PubMed: 29396863
DOI: 10.1002/pro.3383

Experimental method

X-RAY DIFFRACTION (1.86 Å)