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5XYZ

The structure of human BTK kinase domain in complex with a covalent inhibitor

Summary for 5XYZ
Entry DOI10.2210/pdb5xyz/pdb
DescriptorTyrosine-protein kinase BTK, N-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1H-1,2,4-triazol-3-yl)phenyl]propanamide (2 entities in total)
Functional Keywordsbtk, covalent inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q06187
Total number of polymer chains2
Total formula weight62586.82
Authors
Wang, Y.L.,Sun, Y.Z.,Cao, R.,Liu, D.,Xie, Y.T.,Li, L.,Qi, X.B.,Huang, N. (deposition date: 2017-07-11, release date: 2018-05-23, Last modification date: 2023-11-22)
Primary citationWang, Y.,Sun, Y.,Cao, R.,Liu, D.,Xie, Y.,Li, L.,Qi, X.,Huang, N.
In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60:8552-8564, 2017
Cited by
PubMed: 28945083
DOI: 10.1021/acs.jmedchem.7b01075
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.64 Å)
Structure validation

217705

건을2024-03-27부터공개중

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