5XYZ
The structure of human BTK kinase domain in complex with a covalent inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase BTK | polymer | 265 | 30919.6 | 2 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
2 | A, B | N-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1H-1,2,4-triazol-3-yl)phenyl]propanamide | non-polymer | 373.8 | 2 | Chemie (GYL) |
Sequence modifications
A, B: 393 - 656 (UniProt: Q06187)
PDB | External Database | Details |
---|---|---|
Gly 392 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 61839.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 747.6 | |
All* | Total formula weight | 62586.8 |