5XYZ

The structure of human BTK kinase domain in complex with a covalent inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase BTK	polymer	265	30919.6	2	UniProt (Q06187) Pfam (PF07714)	Homo sapiens (Human)	Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase
2	C, D (A, B)	N-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1H-1,2,4-triazol-3-yl)phenyl]propanamide	non-polymer		373.8	2	Chemie (GYL)

Sequence modifications

A, B: 393 - 656 (UniProt: Q06187)

PDB	External Database	Details
Gly 392	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61839.2
Non-Polymers*	Number of molecules	2
	Total formula weight	747.6
All*	Total formula weight	62586.8

*Water molecules are not included.