5XUI

Crystal structure of PDE10A in complex with 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)et hyl]pyrazolo[1,5-a]pyrimidin-7-ol

Summary for 5XUI

• Entry DOI: 10.2210/pdb5xui/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde10a inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 79687.59

Authors

Amano, Y.,Honbou, K. (deposition date: 2017-06-23, release date: 2018-03-14)

• Primary citation: Chino, A.,Seo, R.,Amano, Y.,Namatame, I.,Hamaguchi, W.,Honbou, K.,Mihara, T.,Yamazaki, M.,Tomishima, M.,Masuda, N.; Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors.; Chem. Pharm. Bull., 66:286-294, 2018; PubMed: 29491261; DOI: 10.1248/cpb.c17-00836

Experimental method

X-RAY DIFFRACTION (2.77 Å)