5XUI
Crystal structure of PDE10A in complex with 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)et hyl]pyrazolo[1,5-a]pyrimidin-7-ol
Summary for 5XUI
Entry DOI | 10.2210/pdb5xui/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde10a inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 79687.59 |
Authors | |
Primary citation | Chino, A.,Seo, R.,Amano, Y.,Namatame, I.,Hamaguchi, W.,Honbou, K.,Mihara, T.,Yamazaki, M.,Tomishima, M.,Masuda, N. Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors. Chem. Pharm. Bull., 66:286-294, 2018 Cited by PubMed: 29491261DOI: 10.1248/cpb.c17-00836 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
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