5XRA
Crystal structure of the human CB1 in complex with agonist AM11542
Summary for 5XRA
Entry DOI | 10.2210/pdb5xra/pdb |
Descriptor | Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, ... (7 entities in total) |
Functional Keywords | membrane protein, human g protein-coupled receptor, stabilizing agonists, lipidic cubic phase, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P21554 |
Total number of polymer chains | 1 |
Total formula weight | 51304.17 |
Authors | Hua, T.,Vemuri, K.,Nikas, P.S.,Laprairie, R.B.,Wu, Y.,Qu, L.,Pu, M.,Korde, A.,Shan, J.,Ho, J.H.,Han, G.W.,Ding, K.,Li, X.,Liu, H.,Hanson, M.A.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J. (deposition date: 2017-06-08, release date: 2017-07-12, Last modification date: 2023-11-22) |
Primary citation | Hua, T.,Vemuri, K.,Nikas, S.P.,Laprairie, R.B.,Wu, Y.,Qu, L.,Pu, M.,Korde, A.,Jiang, S.,Ho, J.H.,Han, G.W.,Ding, K.,Li, X.,Liu, H.,Hanson, M.A.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J. Crystal structures of agonist-bound human cannabinoid receptor CB1 Nature, 547:468-471, 2017 Cited by PubMed: 28678776DOI: 10.1038/nature23272 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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