5XRA

Crystal structure of the human CB1 in complex with agonist AM11542

Summary for 5XRA

• Entry DOI: 10.2210/pdb5xra/pdb
• Descriptor: Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, ... (7 entities in total)
• Functional Keywords: membrane protein, human g protein-coupled receptor, stabilizing agonists, lipidic cubic phase, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P21554
• Total number of polymer chains: 1
• Total formula weight: 51304.17

Authors

Hua, T.,Vemuri, K.,Nikas, P.S.,Laprairie, R.B.,Wu, Y.,Qu, L.,Pu, M.,Korde, A.,Shan, J.,Ho, J.H.,Han, G.W.,Ding, K.,Li, X.,Liu, H.,Hanson, M.A.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J. (deposition date: 2017-06-08, release date: 2017-07-12, Last modification date: 2023-11-22)

• Primary citation: Hua, T.,Vemuri, K.,Nikas, S.P.,Laprairie, R.B.,Wu, Y.,Qu, L.,Pu, M.,Korde, A.,Jiang, S.,Ho, J.H.,Han, G.W.,Ding, K.,Li, X.,Liu, H.,Hanson, M.A.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J.; Crystal structures of agonist-bound human cannabinoid receptor CB1; Nature, 547:468-471, 2017; PubMed: 28678776; DOI: 10.1038/nature23272

Experimental method

X-RAY DIFFRACTION (2.8 Å)