5XR8

Crystal structure of the human CB1 in complex with agonist AM841

5XR8 の概要

• エントリーDOI: 10.2210/pdb5xr8/pdb
• 分子名称: Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, ... (6 entities in total)
• 機能のキーワード: membrane protein, human g protein-coupled receptor, stabilizing agonists, lipidic cubic phase, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50022.36

構造登録者

Hua, T.,Vemuri, K.,Nikas, P.S.,Laprairie, R.B.,Wu, Y.,Qu, L.,Pu, M.,Korde, A.,Shan, J.,Ho, J.H.,Han, G.W.,Ding, K.,Li, X.,Liu, H.,Hanson, M.A.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J. (登録日: 2017-06-07, 公開日: 2017-07-12, 最終更新日: 2023-11-22)

• 主引用文献: Hua, T.,Vemuri, K.,Nikas, S.P.,Laprairie, R.B.,Wu, Y.,Qu, L.,Pu, M.,Korde, A.,Jiang, S.,Ho, J.H.,Han, G.W.,Ding, K.,Li, X.,Liu, H.,Hanson, M.A.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J.; Crystal structures of agonist-bound human cannabinoid receptor CB1.; Nature, 547:468-471, 2017; PubMed: 28678776; DOI: 10.1038/nature23272

実験手法

X-RAY DIFFRACTION (2.95 Å)