5XNW

Crystal structure of ExoY, a unique nucleotidyl cyclase toxin from Pseudomonas aeruginosa

5XNW の概要

• エントリーDOI: 10.2210/pdb5xnw/pdb
• 分子名称: Adenylate cyclase ExoY, GLYCEROL, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: nucleotidyl cyclase, virulence effectors, type three secretion system (t3ss), secondary messengers, lyase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42067.34

構造登録者

Khanppnavar, B.,Datta, S. (登録日: 2017-05-24, 公開日: 2018-05-30, 最終更新日: 2023-11-22)

主引用文献

Khanppnavar, B.,Datta, S.
Crystal structure and substrate specificity of ExoY, a unique T3SS mediated secreted nucleotidyl cyclase toxin from Pseudomonas aeruginosa
Biochim. Biophys. Acta, 1862:2090-2103, 2018

PubMed Abstract: The nucleotidyl cyclase toxin ExoY is an important virulence determinant of Pseudomonas aeruginosa that causes severe acute and chronic infections in immune-compromised individuals. Additionally, this unique T3SS effector shows a striking preference for cUMP, a newly identified non-canonical secondary messenger. Thereby, ExoY is also considered as a potential tool to study unexplored cUMP signaling pathways.

PubMed: 29859257
DOI: 10.1016/j.bbagen.2018.05.021

実験手法

X-RAY DIFFRACTION (2.201 Å)