5XN3

Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction

5XN3 の概要

• エントリーDOI: 10.2210/pdb5xn3/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002275
• 分子名称: SPRY domain-containing SOCS box protein 2, cR8 peptide from NOS2 (3 entities in total)
• 機能のキーワード: e3 ubiquitin, ligase, cyclic peptide inhibitor, spry domain-containing, socs box protein, inducible nitric oxide synthase, nitric oxide, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : Q99619
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23798.55

構造登録者

You, T.,Kuang, Z. (登録日: 2017-05-17, 公開日: 2017-06-14, 最終更新日: 2023-11-22)

• 主引用文献: You, T.,Wang, Y.,Li, K.,Zhang, D.,Wei, H.,Luo, Y.,Li, H.,Lu, Y.,Su, X.,Kuang, Z.; Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.; Biochem. Biophys. Res. Commun., 489:346-352, 2017; PubMed: 28549582; DOI: 10.1016/j.bbrc.2017.05.122

実験手法

X-RAY DIFFRACTION (1.34 Å)