5XMX

Co-crystal structure of Inhibitor compound in complex with human PPARdelta LBD

5XMX の概要

• エントリーDOI: 10.2210/pdb5xmx/pdb
• 分子名称: Peroxisome proliferator-activated receptor delta, (E)-6-[2-[[[4-(furan-2-yl)phenyl]carbonyl-methyl-amino]methyl]phenoxy]-4-methyl-hex-4-enoic acid (3 entities in total)
• 機能のキーワード: ppardelta, inhibitor compound, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q03181
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63728.06

構造登録者

Lakshminarasimhan, A.,Rani, S.T.,Senaiar, R.S.,Krishnamurthy, N. (登録日: 2017-05-16, 公開日: 2018-05-23, 最終更新日: 2023-11-22)

• 主引用文献: Lagu, B.,Kluge, A.F.,Fredenburg, R.A.,Tozzo, E.,Senaiar, R.S.,Jaleel, M.,Panigrahi, S.K.,Tiwari, N.K.,Krishnamurthy, N.R.,Takahashi, T.,Patane, M.A.; Novel highly selective peroxisome proliferator-activated receptor delta (PPAR delta) modulators with pharmacokinetic properties suitable for once-daily oral dosing.; Bioorg. Med. Chem. Lett., 27:5230-5234, 2017; PubMed: 29103972; DOI: 10.1016/j.bmcl.2017.10.037

実験手法

X-RAY DIFFRACTION (2 Å)