5XMH
Crystal structure of an IgM rheumatoid factor YES8c in complex with IgG1 Fc
Summary for 5XMH
Entry DOI | 10.2210/pdb5xmh/pdb |
Descriptor | Immunoglobulin gamma-1 heavy chain, YES8c light chain, YES8c heavy chain, ... (6 entities in total) |
Functional Keywords | immunoglobulin, complex, rheumatoid factor, autoantibody, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P0DOX5 |
Total number of polymer chains | 6 |
Total formula weight | 144696.60 |
Authors | Shiroishi, M.,Shimokawa, K.,Lee, J.M.,Kusakabe, M.,Ueda, T. (deposition date: 2017-05-15, release date: 2018-03-21, Last modification date: 2020-07-29) |
Primary citation | Shiroishi, M.,Ito, Y.,Shimokawa, K.,Lee, J.M.,Kusakabe, T.,Ueda, T. Structure-function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity. J. Biol. Chem., 293:7008-7016, 2018 Cited by PubMed: 29523691DOI: 10.1074/jbc.M117.814475 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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