5XMC

Crystal structure of the auto-inhibited Nedd4 family E3 ligase Itch

Summary for 5XMC

Entry DOI	10.2210/pdb5xmc/pdb
Descriptor	E3 ubiquitin-protein ligase Itchy (2 entities in total)
Functional Keywords	auto-inhibited itch, ligase
Biological source	Mus musculus (Mouse)
Cellular location	Cell membrane : Q8C863
Total number of polymer chains	1
Total formula weight	83412.20
Authors	Shan, Z.,Wen, W. (deposition date: 2017-05-13, release date: 2017-08-02, Last modification date: 2023-11-22)
Primary citation	Zhu, K.,Shan, Z.,Chen, X.,Cai, Y.,Cui, L.,Yao, W.,Wang, Z.,Shi, P.,Tian, C.,Lou, J.,Xie, Y.,Wen, W. Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch EMBO Rep., 18:1618-1630, 2017 Cited by PubMed: 28747490 DOI: 10.15252/embr.201744454 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation