5XJ3

Complex structure of ipilimumab-scFv and CTLA-4

Summary for 5XJ3

• Entry DOI: 10.2210/pdb5xj3/pdb
• Related: 5XJ4
• Descriptor: ipilimumab-VH, ipilimumab-VL, Cytotoxic T-lymphocyte protein 4 (3 entities in total)
• Functional Keywords: ipilimumab, ctla-4, complex structure, immune system
• Biological source: Homo sapiens; More
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P16410
• Total number of polymer chains: 12
• Total formula weight: 154673.56

Authors

He, M.,Chai, Y.,Qi, J.,Tong, Z.,Tan, S.,Gao, G.F. (deposition date: 2017-04-29, release date: 2018-04-25, Last modification date: 2023-11-22)

• Primary citation: He, M.,Chai, Y.,Qi, J.,Zhang, C.W.H.,Tong, Z.,Shi, Y.,Yan, J.,Tan, S.,Gao, G.F.; Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies; Oncotarget, 8:67129-67139, 2017; PubMed: 28978021; DOI: 10.18632/oncotarget.18004

Experimental method

X-RAY DIFFRACTION (3.2 Å)