5XJ3
Complex structure of ipilimumab-scFv and CTLA-4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0006955 | biological_process | immune response |
| C | 0016020 | cellular_component | membrane |
| C | 0042129 | biological_process | regulation of T cell proliferation |
| F | 0006955 | biological_process | immune response |
| F | 0016020 | cellular_component | membrane |
| F | 0042129 | biological_process | regulation of T cell proliferation |
| I | 0006955 | biological_process | immune response |
| I | 0016020 | cellular_component | membrane |
| I | 0042129 | biological_process | regulation of T cell proliferation |
| L | 0006955 | biological_process | immune response |
| L | 0016020 | cellular_component | membrane |
| L | 0042129 | biological_process | regulation of T cell proliferation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Region: {"description":"Homodimerization","evidences":[{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Important for interaction with CD80 and CD86","evidences":[{"source":"PubMed","id":"28484017","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
