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5XAG

Crystal structure of tubulin-stathmin-TTL-Compound Z2 complex

Summary for 5XAG
Entry DOI10.2210/pdb5xag/pdb
Related5XAF
DescriptorTubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (3~{R},4~{R})-3-(hydroxymethyl)-4-(4-methoxy-3-oxidanyl-phenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, ... (14 entities in total)
Functional Keywordstubulin, structural protein
Biological sourceBos taurus (Bovine)
More
Cellular locationCytoplasm, cytoskeleton: P81947 Q6B856
Golgi apparatus : P63043
Total number of polymer chains6
Total formula weight271049.74
Authors
Zhang, H.,Luo, C.,Wang, Y. (deposition date: 2017-03-12, release date: 2018-01-03, Last modification date: 2023-11-22)
Primary citationZhou, P.,Liang, Y.,Zhang, H.,Jiang, H.,Feng, K.,Xu, P.,Wang, J.,Wang, X.,Ding, K.,Luo, C.,Liu, M.,Wang, Y.
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144:817-842, 2017
Cited by
PubMed: 29306206
DOI: 10.1016/j.ejmech.2017.12.004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.56 Å)
Structure validation

217705

数据于2024-03-27公开中

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