5X8Q

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.

5X8Q の概要

• エントリーDOI: 10.2210/pdb5x8q/pdb
• 関連するPDBエントリー: 5X8S 5X8U 5X8W 5X8X
• 分子名称: Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (1R,2S,4S,5'R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-10,16-diol, ... (4 entities in total)
• 機能のキーワード: inhibitor, ternary complex, nuclear receptor, transferase-ihibitor complex, transferase/ihibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : P51449 Q9Y618
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 131147.74

構造登録者

Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Adachi, T. (登録日: 2017-03-03, 公開日: 2017-06-07, 最終更新日: 2023-11-22)

• 主引用文献: Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Hirata, K.,Shiozaki, M.,Hirashima, S.,Kotoku, M.,Yamaguchi, T.,Katsuda, Y.,Steensma, R.,Li, X.,Tao, H.,Tse, B.,Fenn, M.,Babine, R.,Bradley, E.,Crowe, P.,Thacher, S.,Adachi, T.,Kamada, M.; Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment; Genes Cells, 22:535-551, 2017; PubMed: 28493531; DOI: 10.1111/gtc.12494

実験手法

X-RAY DIFFRACTION (2.2 Å)