5X7E
Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D2
Summary for 5X7E
Entry DOI | 10.2210/pdb5x7e/pdb |
Descriptor | Vitamin D3 dihydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5,6-dimethyl-6-oxidanyl-hept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydr o-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total) |
Functional Keywords | metal-binding, monooxygenase, oxidoreductase |
Biological source | Streptomyces griseolus |
Cellular location | Cytoplasm : P18326 |
Total number of polymer chains | 1 |
Total formula weight | 46036.88 |
Authors | Hayashi, K.,Yasuda, K.,Shiro, Y.,Sugimoto, H.,Sakaki, T. (deposition date: 2017-02-25, release date: 2017-05-10, Last modification date: 2023-11-22) |
Primary citation | Yasuda, K.,Yogo, Y.,Sugimoto, H.,Mano, H.,Takita, T.,Ohta, M.,Kamakura, M.,Ikushiro, S.,Yasukawa, K.,Shiro, Y.,Sakaki, T. Production of an active form of vitamin D2 by genetically engineered CYP105A1 Biochem. Biophys. Res. Commun., 486:336-341, 2017 Cited by PubMed: 28302483DOI: 10.1016/j.bbrc.2017.03.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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