5X7E

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D2

Summary for 5X7E

Entry DOI	10.2210/pdb5x7e/pdb
Descriptor	Vitamin D3 dihydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5,6-dimethyl-6-oxidanyl-hept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydr o-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
Functional Keywords	metal-binding, monooxygenase, oxidoreductase
Biological source	Streptomyces griseolus
Cellular location	Cytoplasm : P18326
Total number of polymer chains	1
Total formula weight	46036.88
Authors	Hayashi, K.,Yasuda, K.,Shiro, Y.,Sugimoto, H.,Sakaki, T. (deposition date: 2017-02-25, release date: 2017-05-10, Last modification date: 2023-11-22)
Primary citation	Yasuda, K.,Yogo, Y.,Sugimoto, H.,Mano, H.,Takita, T.,Ohta, M.,Kamakura, M.,Ikushiro, S.,Yasukawa, K.,Shiro, Y.,Sakaki, T. Production of an active form of vitamin D2 by genetically engineered CYP105A1 Biochem. Biophys. Res. Commun., 486:336-341, 2017 Cited by PubMed: 28302483 DOI: 10.1016/j.bbrc.2017.03.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation