5X21

Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM)

Summary for 5X21

Entry DOI	10.2210/pdb5x21/pdb
Related	5x22
Descriptor	DNA-directed RNA polymerase subunit alpha, ZINC ION, (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, ... (12 entities in total)
Functional Keywords	transcription, rna polymerase, transcription inhibition, nucleoside-analog inhibitor, pseudouridimycin, transferase-dna complex, transferase/dna
Biological source	Thermus thermophilus More
Cellular location	Cytoplasm : Q72L95
Total number of polymer chains	9
Total formula weight	445097.09
Authors	Zhang, Y.,Ebright, R. (deposition date: 2017-01-29, release date: 2017-07-05, Last modification date: 2022-10-12)
Primary citation	Maffioli, S.I.,Zhang, Y.,Degen, D.,Carzaniga, T.,Del Gatto, G.,Serina, S.,Monciardini, P.,Mazzetti, C.,Guglierame, P.,Candiani, G.,Chiriac, A.I.,Facchetti, G.,Kaltofen, P.,Sahl, H.G.,Deho, G.,Donadio, S.,Ebright, R.H. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169:1240-1248.e23, 2017 Cited by PubMed: 28622509 DOI: 10.1016/j.cell.2017.05.042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.323 Å)

Structure validation